{"id":5367,"date":"2026-10-29T20:32:34","date_gmt":"2026-10-29T20:32:34","guid":{"rendered":"https:\/\/www.stamm.bio\/?p=5367"},"modified":"2026-11-03T13:06:44","modified_gmt":"2026-11-03T13:06:44","slug":"htb-crossing-over-2026","status":"publish","type":"post","link":"https:\/\/www.stamm.bio\/es\/htb-crossing-over-2026\/","title":{"rendered":"Cultivo celular sin burbujas: el HTB en Crossing Over"},"content":{"rendered":"\n

Si hoy los mejores deportistas del mundo buscan en sus propias c\u00e9lulas la soluci\u00f3n a una lesi\u00f3n, \u00bfc\u00f3mo hacemos para que esa puerta se abra para cualquiera? Con esa pregunta, Juan Mart\u00edn Cabaleiro, nuestro CTO, abri\u00f3 su charla en Crossing Over Latam el 21 de octubre. Y no vino solo: el equipo de St\u00e4mm mont\u00f3 un stand con el High-Throughput Bioprocessor (HTB) funcionando, demos en vivo y varios St\u00e4mmers se quedaron conversando con quienes se acercaron.<\/p>\n\n\n\n

Tres ideas de la charla<\/h2>\n\n\n\n
    \n
  1. Lo que importa es c\u00f3mo les pedimos a las c\u00e9lulas que trabajen.<\/strong> Los biorreactores de tanque agitado dependen de h\u00e9lices, burbujas y spargers que generan turbulencia y espuma, y se corrigen con antiespumante. Los cultivos de c\u00e9lulas adherentes, en cambio, siguen apoy\u00e1ndose en frascos y pilas de placas con muchos pasos manuales.<\/li>\n\n\n\n
  2. La naturaleza cultiva de otra manera.<\/strong> Sus flujos son laminares, el gas se transporta de forma pasiva y en lugar de h\u00e9lices hay sistemas vasculares. De ah\u00ed sale el dise\u00f1o del HTB, que toma al cuerpo humano como modelo: una unidad de control con sensores (el sistema nervioso), bombas perist\u00e1lticas (el coraz\u00f3n), tubos microflu\u00eddicos (los vasos sangu\u00edneos) y una unidad de formulaci\u00f3n junto con el biorreactor (el sistema digestivo y los pulmones).<\/li>\n\n\n\n
  3. El Bubble-Free Bioreactor (BFB) adapta el sistema a la c\u00e9lula.<\/strong> Es un cartucho impreso en 3D, basado en giroides, en un material biocompatible que deja pasar los gases pero no los l\u00edquidos. No hay burbujas, spargers ni antiespumante: el ox\u00edgeno atraviesa la pared y el medio fluye en perfusi\u00f3n continua. Sirve para c\u00e9lulas en suspensi\u00f3n y para c\u00e9lulas adherentes, con cartuchos distintos. El BFB de 60 mL ofrece una capacidad equivalente a m\u00e1s de siete frascos T175 y desde una sola unidad de control se operan hasta tres unidades de producci\u00f3n en paralelo.<\/li>\n<\/ol>\n\n\n\n

    Lo que se vio en el estand<\/h2>\n\n\n\n

    Martina Porto, Agustina Thibaud, Marco Sottile, Imano Ag\u00fcero y Ludmila Budzynski mostraron el sistema en vivo: la toma de muestra y la inoculaci\u00f3n paso a paso desde la pantalla de control, con un indicador de color para ver c\u00f3mo se homogeneiza el in\u00f3culo.<\/p>\n\n\n\n

    Sobre St\u00e4mm<\/h2>\n\n\n\n

    St\u00e4mm es una empresa de biomanufactura con equipos en San Francisco, Buenos Aires y Monthey (Suiza). Naci\u00f3 de dos primos que quer\u00edan cambiar la biomanufactura, pas\u00f3 por Singularity University, GridX e IndieBio, y hoy desarrolla plataformas automatizadas inspiradas en la naturaleza para descentralizar la producci\u00f3n biol\u00f3gica.<\/p>\n\n\n\n

    Ya disponible para investigaci\u00f3n<\/h2>\n\n\n\n

    El HTB y el BFB est\u00e1n a la venta para uso en investigaci\u00f3n (RUO): no son para diagn\u00f3stico ni para uso cl\u00ednico. Los dise\u00f1amos pensando en GMP y esa ruta est\u00e1 en nuestro roadmap. Buscamos partners para construir esto juntos.<\/p>\n\n\n\n

    \u00bfQuer\u00e9s verlo funcionando en tu laboratorio? [link de contacto]. Mir\u00e1 la demo completa: [link a la demo]. Comprar: [link a la compra].<\/p>\n\n\n\n

    Gracias a la organizaci\u00f3n de Crossing Over por el espacio, y a quienes se acercaron con preguntas.<\/p>\n","protected":false},"excerpt":{"rendered":"

    Nuestro CTO present\u00f3 en Crossing Over, en Buenos Aires, el HTB: un biorreactor de mesa que cultiva c\u00e9lulas sin burbujas ni impulsores. Disponible para investigaci\u00f3n (RUO).<\/p>\n","protected":false},"author":2,"featured_media":5335,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":"","_links_to":"","_links_to_target":""},"categories":[78,47],"tags":[],"class_list":["post-5367","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-in-the-news","category-global-events"],"acf":[],"yoast_head":"\nCultivo celular sin burbujas: el HTB en Crossing Over - St\u00e4mm<\/title>\n<meta name=\"description\" content=\"Nuestro CTO present\u00f3 en Crossing Over, en Buenos Aires, el HTB: un biorreactor de mesa que cultiva c\u00e9lulas sin burbujas ni impulsores. 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